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Biological indicators for the assessment of human exposure to organophosphorous compounds.

Autor: Podolak M, Panasiuk L.


Tíetulo en español: Indicadores biológicos para la evaluaicón de la exposición humana a compuestos órganofosforados

Publicación: Przegl Lek. 1997;54(10):719-22.Department of Biochemistry, Faculty of Veterinary Medicine, Agricultural University in Lublin.

Tipo documento: Journal article Publication Types: * Clinical Trial * Controlled Clinical Trial

Abstract: The aim of the present study is to review selected biological effects of organophosphorous compounds used as pesticides and to discuss their significance in terms of occupational exposure. The results of a long-term study of the red cells and plasma ChE in group of workers engaged in the production of pesticides are also presented. Cholinesterase activity in plasma and red blood cells was determined spectrophotometrically by the Ellman modified method. Occupational exposure to pesticides was analysed by the Durham and Wolf method. Conclusions: 1. Cholinesterase activity in blood serum of the workers employed at the production of organophosphorous compounds is statistically significantly lower, compared to the control group and the lower accepted standard limit. 2. Cholinesterase activity in plasma seems to be a more sensitive indicator of exposure, compared to the activity of enzyme contained in erythrocytes after a long-lasting exposure to low levels of organophosphorous compounds. 3. Changes in cholinesterase activity according to the level of exposure show a better correlation if the exposure is expressed in % of the toxic dose/day than in mg/day. Toxicological properties of organophosphorous compounds are of the great importance for this correlation.
PMID: 9478093

Biomarkers in Risk Assesment: Validity and Validation

Nombre del artículo en español: Biomarcadores en evaluación de riesgo: validez y validación

Autor (es): WHO. International Programme on Chemical Safety

Publicación (nombre, volumen, nº, fecha, página): Environmental Health Criteria 222. Año 2001

Tipo de publicación: libro 238 páginas

Tipo de documento: Monografía



Abstract original (transcripción: Reporte de grupos internacionales de expertos publicado con el auspicio de United Nations Environment Programm, ILO, OMS e Inter-Organization Programme for the Sound Management of Chemicals. Monografía que revisa los efectos de los químicos en la salud humana y en el ambiente y la combinación de éstos con los agentes físicos y biológicos. Define lo que es un biomarcador y el uso en la evaluación del riesgo, cómo éste se identifica y cómo se evalúa la exposición. En los capítulos siguientes se refiere a los biomarcadores de exposición y efecto para carcinogénicos, nefro, neumo y neurotóxicos. Luego recopila la información de la medición de polimorfismos de enzimas metabolizadotas como indicadores de susceptibilidad. El último capítulo se refiere a la validación de biomarcadores para la investigación en salud ambiental y la evaluación de riesgo.
NTP 660: Control biológico de trabajadores expuestos a plaguicidas (II): técnicas específicas

Autor (es) Obiols Quinto, Jordi

Publicación NTP 661.Instituto Nacional de Condiciones del Trabajo de España. Centro Nacional de Condiciones de Trabajo

Tipo de publicación: 1999. Notas técnicas de prevención de 11 páginas

Tipo de documento (artículo, investigación original, revisión sistemática, metanálisis, protocolo, guía, norma, legal) Notas técnicas de prevención

Para artículos de investigación original::

tipo de investigación o diseño: no aplica

País no aplica

Fuente de origen (base indexada, literatura gris): no aplica

Palabras clave: no aplica

Abstract original (transcripción): Aparte del uso genérico del control de plagas al que van destinados los plaguicidas, las diferencias existentes entre ellos son abismales desde el punto de vista químico, biológico y toxicológico. Ello determina que, en la práctica, la forma de realizar el control biológico dependa del agente químico en concreto al que esté expuesto el trabajador, no existiendo ningún indicador biológico universal aplicable a todos ellos. Lo expuesto en la presente NTP, continuación de la NTP 660 es aplicable a trabajadores expuestos a un solo agente o a un solo tipo de agente; en caso contrario, debe tenerse en cuenta la posibilidad de interacciones entre distintos agentes, grupos a los que pertenecen u otros posibles mecanismos toxicológicos con otros agentes con los que no tienen ninguna relación química.
Biomonitoring of Exposure in Farmworker Studies

Autor: Barr DB, Thomas K, Curwin B, Landsittel D, Raymer J, Lu C, Donnelly KC, Acquavella J.


Publicación: Environ Health Perspect. 2006 Jun;114(6):936-42.
Tipo documento: Publication Types:* Research Support, N.I.H., Extramural * Research Support, Non-U.S. Gov't * Review
Abstract: Although biomonitoring has been used in many occupational and environmental health and exposure studies, we are only beginning to understand the complexities and uncertainties involved with the biomonitoring process--from study design, to sample collection, to chemical analysis--and with interpreting the resulting data. We present an overview of concepts that should be considered when using biomonitoring or biomonitoring data, assess the current status of biomonitoring, and detail potential advancements in the field that may improve our ability to both collect and interpret biomonitoring data. We discuss issues such as the appropriateness of biomonitoring for a given study, the sampling time frame, temporal variability in biological measurements to nonpersistent chemicals, and the complex issues surrounding data interpretation. In addition, we provide recommendations to improve the utility of biomonitoring in farmworker studies.
PMID: 16759998 [PubMed - indexed for MEDLINE]

Titre du document / Document title : Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity

Auteur(s) / Author(s)COSTA Lucio G. ; COLE Toby B. ; VITALONE Annabella ; FURLONG Clement E. ;


Título en español: Medición del estado de paraoxonasa (PON1) como un potencial biomarcador de susceptibilidad a toxicidad por órganofosforados.

Publicacion: : Clin Chim Acta. 2005 Feb;352(1-2):37-47 Full Text: http://cat.inist.fr/?aModele=afficheN&cpsidt=1727753

Tipo documento: Review: Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Résumé / Abstract


Organophosphorus (OP) compounds are still among the most widely used insecticides, and their main mechanism of acute toxicity is associated with inhibition of acetylcholinesterase. Measurements of urine metabolites and ofblood cholinesterase activity are established biomarkers of exposure to OPs and of early biological effects. In recent years, increasing attention has been given to biomarkers of susceptibility to OP toxicity. Here we discuss the polymorphisms of paraoxonase (PON1), a liver and serum enzyme that hydrolyzes a number of OP compounds, and its role in modulating the toxicity of OPs. We stress the importance of determining PON1 status, which encompasses the PON1192Q/R polymorphism (that affects catalytic ability toward different substrates) and PON1 levels (which are modulated in part by a C-108T polymorphism) over straight genotyping. Epidemiological studies on OP-exposed workers that include assessment of PON1 status to validate in human populations the role of PON1 as a determinant of susceptibility to OPs, as indicated by animal studies, are needed. Documentation of exposure and of early health effects would be most relevant to increase the predictive value of the test.

Langue / Language Anglais

Editeur / Publisher Elsevier, Shannon, IRLANDE  (1956) (Revue)
Localisation / Location INIST-CNRS, Cote INIST : 6270, 35400012613643.0030


PMID: 15653099 [PubMed - indexed for MEDLINE]
Abnormal cholinesterase activity: understanding and interpretation.

Autor: Jokanović, M., Maksimović, M. Department of Toxicology, Faculty of Pharmacy, University of Belgrade, Belgrade,

Publicación: European journal of clinical chemistry and clinical biochemistry   ISSN 0939-4974 . 1997, vol. 35, no1, pp. 11-16 (25 ref.) http://journals.elsevierhealth.com/periodicals/ymai/medline/record/MDLN.9156559

Tipo documento: Journal Article; Review



Abstract: Abnormal acetylcholinesterase and cholinesterase activity may occur due to a) various physiological and pathological conditions, b) genetic factors or c) interaction with drugs and cholinesterase inhibitors. This paper reviews and discusses such conditions in which both cholinesterases show abnormal activity focusing on better understanding and interpretation of laboratory results. In particular, the mechanism of interaction of both cholinesterases with their inhibitors such as organophosphorus and carbamate compounds is discussed. Some practical recommendations concerning sampling and preparation of samples for enzyme assay are given in order to avoid errors that may affect laboratory findings.

Palabras claves: MeSH:Acetylcholinesterase; Carbamates; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Humans; Organophosphorus Compounds



Language: english

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