Autor: : Palacios-Nava ME, Paz-Román P, Hernández-Robles S, Mendoza-Alvarado L.
Título en español: Sintomatología persistente en trabajadores industriales expuestos a pesticidas organofosforados
Publicación: Salud Publica Mex. 1999 Jan-Feb;41(1):55-61.
Tipo de documento: Journal Article
[Article in Spanish]
Departamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México.
Abstract: To describe the patterns of persistent symptomatology in workers industrially exposed to organophosphate pesticides. MATERIAL AND METHODS: An observational, descriptive and cross-sectional study was performed. A questionnaire was applied to managers of a factory and to 89 workers, whose erythrocytic cholinesterase level was measured with the Magnotti and Lovibond method. Information is described through rates, central tendency measures and dispersion. Differences between groups were evaluated with the chi 2 test and the odds ratio was calculated. RESULTS: Persistent symptomatology was found in 6.3 per 10 workers. 50% had six or more symptoms. No significant differences were found as to the risk of suffering from persistent symptomatology with respect to age, length of service or position at work. However, the highest proportion of symptoms was found in workers of 31 to 40 years of age, with 6 to 13 years of service, from the maintenance area, working as general operators or supervisors. Among the 13 workers with previous intoxication, the prevalence of persistent symptomatology was 6.9 against 6.1 in workers who had not been intoxicated before. The risk of acute poisoning in workers with more than 14 years of service was 4 times greater than in workers with less than 14 years of service (p < 0.005). Average level of blood cholinesterase was normal (4.4 u/ml). CONCLUSIONS: Results show a relationship between exposure to organophosphate pesticides and presence of persistent symptoms. It is necessary to study the prevalence of this symptomatology in exposed and non-exposed populations.
MH- AdultMH- *Chemical IndustryMH- Cholinesterases/blood/drug effectsMH- Clinical Enzyme Tests/methodsMH- Cross-Sectional StudiesMH- Erythrocytes/drug effects/enzymologyMH- FemaleMH- HumansMH- Insecticides/*adverse effects/poisoningMH- MaleMH- MexicoMH- Middle AgedMH- Occupational Diseases/diagnosisMH- Occupational Exposure/*adverse effects/statistics & numerical dataMH- *Organophosphorus CompoundsMH- Poisoning/diagnosisMH- QuestionnairesMH- Risk FactorsMH- Time Factors
PMID: 10081334 [PubMed - indexed for MEDLINE
Titre du document / Document title: Toxicity due to organophosphorus compounds: what about chronic exposure?
Auteur(s) / Author(s DE SILVA H. J. (1) ; SAMARAWICKREMA N. A. (2) ; WICKREMASINGHE A. R. (3) ;
Título en español: Toxicidad debido a compuestos organofosforados: ¿Qué hay sobre la exposición crónica?
Résumé / Abstract
The inappropriate use of toxic chemicals is common in developing countries, where it leads to excessive exposure and high risks of unintentional poisoning. The risks are particularly high with the pesticides used in agriculture, where poor rural populations live and work in close proximity to these compounds, which are often stored in and around the home. It is estimated that 99% of all deaths from pesticide poisoning occur in developing countries. Whilst the acute toxicity of pesticides has been well documented, there is still relatively little known of the effects on health of chronic pesticide exposure. Organophosphate insecticides have been extensively used in agriculture in developing countries, with little protection for the communities and individuals thus exposed. Given the indisputable chronic exposure of vulnerable groups to organophosphate compounds, including pregnant women, the fetus and young children, the potential for widespread adverse effects is considerable. Thus, whilst there is some evidence that chronic exposure may have adverse effects on health, there is an urgent need for high-quality observational and interventional studies of both occupational and environmental exposure to these compounds.
Revue / Journal Title
Transactions of the Royal Society of Tropical Medicine and Hygiene ISSN 0035-9203 CODEN TRSTAZ
Source / Source
2006, vol. 100, no9, pp. 803-806 [4 page(s) (article)] (1 p.1/4)
Langue / Language
Editeur / Publisher
Elsevier, Oxford, ROYAUME-UNI (1907) (Revue)
Pesticides ; Public health ; Tropical medicine ; Environment ; Exposure ; Chronic ; Insecticide ; Organophosphorus compounds ; Toxicity ; Poisoning ;
Pesticide ; Santé publique ; Médecine tropicale ; Environnement ; Exposition ; Chronique ; Insecticide ; Organophosphoré ; Toxicité ; Intoxication ;
Mots-clés espagnols / Spanish Keywords
Plaguicida ; Salud pública ; Medicina tropical ; Medio ambiente ; Exposición ; Crónico ; Insecticida ; Organofosforado ; Toxicidad ; Intoxicación ;
Mots-clés d'auteur / Author Keywords
Organophosphate pesticides ; Unintentional poisoning ; Environmental exposure ; Insecticides ;
Localisation / Location
INIST-CNRS, Cote INIST : 3084, 35400013905311.0010
Long-term use of organophosphates and neuropsychological performance
Autor: Nancy Fiedler, PhD 1 *, Howard Kipen, MD, MPH 1, Kathie Kelly-McNeil, BA 1, Richard Fenske, PhD, MPH 2 1University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey
2Department of Environmental Health, University of Washington, Seattle, Washington
Titulo en español: El uso a largo plazo de los organofosforados y el rendimiento neuropsicológico
Publicación: Am. J. Ind. Med. 32:487-496, 1997. © 1997 Wiley-Liss, Inc.
Tipo de documento: Journal article. Estudio de caso control
Abstract This study evaluated neuropsychological effects due to chronic organophosphate use among farmers with no history of acute poisoning. Fifty-seven male tree fruit farmers (exposed) were compared with 42 age-matched male cranberry/blueberry growers and hardware store owners (unexposed). Univariate analyses of covariance (reading test as covariate) comparing exposed and unexposed subjects revealed significantly slower reaction time. No other significant differences were noted on tests of concentration, visuomotor skills, memory, expressive language, or mood. Based on an exposure metric derived from detailed exposure histories, farmers were divided into high exposure (n = 40) and low exposure (n = 59) groups, and their neuropsychological performance was compared. Analysis of covariance with age and reading test score as covariates revealed that the high exposure group had significantly slower reaction time, dominant hand. Long-term use of organophosphates without evidence of an acute poisoning episode appears to produce, at most, subtle changes in neuropsychological performance
Keywords organophosphates • neuropsychological • farmers • reaction time • exposure metric
Título: Vigilancia de las Intoxicaciones con Plaguicidas en Colombia
Autor: ALVARO JAVIER IDROVO
Publicación : Int J Environ Health Res. 2005 Jun;15(3):161-9.
Tipo de documento: Journal Article
El objetivo del presente trabajo es revisar críticamente la forma en la cual se lleva a cabo la vigilancia epidemiológica de los efectos sobre la salud asociados con la exposición a plaguicidas en Colombia. Para tal fin, primero se describen los cambios históricos en la exposición a los plaguicidas en el país, se plantean los esperados y potenciales efectos adversos sobre la salud (crónicos, agudos y sub-agudos). Luego se revisan algunos de los sistemas de vigilancia epidemiológica existentes en el país, se analizan sus fortalezas y debilidades, y por último se proponen algunas pautas básicas para mejorar dicha labor.
Palabras claves: Plaguicida, vigilancia epidemiológica, Colombia, salud pública.