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A survey of semen indices in insecticide sprayers.

Autor: Kamijima M, Hibi H, Gotoh M, Taki K, Saito I, Wang H, Itohara S, Yamada T, Ichihara G, Shibata E, Nakajima T, Takeuchi Y.

Publicación: J Occup Health. 2004 Mar;46(2):109-18.

Publication Types: * Comparative Study

Abstract: This study aims at clarifying the semen indices of insecticide sprayers who are exposed mainly to organophosphorus and pyrethroid insecticides. Eighteen male sprayers out of 54 working for 9 companies in central Japan and 18 age-matched students or medical doctors as unexposed controls participated in detailed reproductive check-ups conducted in summer and the following winter. The sprayers were exposed to insecticides more in summer, the busiest season, than winter, the off-season (p<0.05). Erythrocyte true cholinesterase activities in the sprayers were lower than in the controls in summer (p<0.05), and decreased in significant association with the increase in exposure frequency. Testicular volumes in the sprayers tended to be smaller than in the controls (p=0.06). The serum testosterone concentration in winter in the sprayers was higher than in the controls (p<0.05), though luteinizing hormone and follicle stimulating hormone concentrations were not significantly different. The sperm counts and vitality were comparable between the groups, but detailed sperm motility analysis in summer revealed that the percentages of slow progressive and nonprogressive motile sperm were twice as high in the sprayers (p<0.05), and that of rapid progressive sperm tended to be lower (p=0.06). Such differences were not observed in winter. Differential sperm morphology counts showed that interaction of group and abstinence effects were significant in sperm with normal morphology and with head deformity only in the summer check-up. Despite possible inherent differences between the groups, the above season-dependent differences suggested that the observed lower semen quality in the sprayers was associated with pesticide spraying work

Palabras clave: Occupational/*toxicity Follicle Stimulating Hormone/blood - Health Surveys - Insecticides/*toxicity - Luteinizing Hormone/blood - Occupational Exposure/*adverse effects - Semen/cytology/*drug effects *Sperm Count

- Sperm Motility/*drug effects - Testosterone/blood

PMID: 15090685 [PubMed - indexed for MEDLINE]

Reduction in fertility in male greenhouse workers exposed to pesticides.

Autor: Petrelli G, Figà-Talamanca I.

Publicación: Eur J Epidemiol. 2001;17(7):675-7.

Abstract: - The paper examines the possible interference of pesticide exposure on male fertility, by studying the time to pregnancy (TTP) in the first pregnancy of 127 greenhouse workers and 173 controls. The TTP of exposed and control population, analysed by logistic regression model, has shown an increase in the risk of conception delay among the greenhouse workers with high exposure (OR:2.4; 95% CI: 1.2-5.1).

Palabras clave: Infertility, Male/*chemically induced - Logistic Models - Occupational Exposure/*adverse effects - Paternal Exposure/*adverse effects - Pesticides/*adverse effects - Proportional Hazards Models

PMID- 12086082

Human reproductive system disturbances and pesticide exposure in Brazil.

Autor: Koifman S, Koifman RJ, Meyer A.

Publicación: Cad Saude Publica. 2002 Mar-Apr;18(2):435-45. Epub 2002 Aug 16.

Publication type: Journal article. Ecologic study

Abstract The observation of reproductive disturbances in humans and in the wildlife has been reported in the last decade in different countries. Exposure to different chemicals possibly acting in the endocrine system or endocrine disruptors, including pesticides, has been a hypothesis raised to explain the observed changes. This paper aimed to present results of an epidemiological ecologic study carried out to explore population data on pesticides exposure in selected Brazilian states in the eighties and human reproductive outcomes in the nineties. Pearson correlation coefficients were ascertained between available data pesticides sales in eleven states in Brazil in 1985 and selected further reproductive outcomes or their surrogates. Moderate to high correlations were observed to infertility, testis, breast, prostate and ovarian cancer mortality. Despite the restrains of ecologic studies to establish cause-effect relationships, the observed results are in agreement with evidence supporting a possible association between pesticides exposure and the analyzed reproductive outcomes.

Palabras clave : - Breast Neoplasms/epidemiology - Commerce/statistics & numerical data - Endocrine System/drug effects - Epidemiologic Studies - Incidence

- Infertility/chemically induced/epidemiology - Occupational Exposure/*adverse effects/statistics & numerical data

PMID- 11923885

An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population.

Autor: Arbuckle TE, Lin Z, Mery LS

Publicación: Environ Health Perspect. 2001 Aug;109(8):851-7.Click here to read

Publication Types: Estudio retrospective * Research Support, U.S. Gov't, P.H.S. PG - 851-7

Abstract: The toxicity of pesticides on human reproduction is largely unknown--particularly how mixtures of pesticide products might affect fetal toxicity. The Ontario Farm Family Health Study collected data by questionnaire on the identity and timing of pesticide use on the farm, lifestyle factors, and a complete reproductive history from the farm operator and eligible couples living on the farm. A total of 2,110 women provided information on 3,936 pregnancies, including 395 spontaneous abortions. To explore critical windows of exposure and target sites for toxicity, we examined exposures separately for preconception (3 months before and up to month of conception) and postconception (first trimester) windows and for early (< 12 weeks) and late (12-19 weeks) spontaneous abortions. We observed moderate increases in risk of early abortions for preconception exposures to phenoxy acetic acid herbicides [odds ratio (OR) = 1.5; 95% confidence interval (CI), 1.1-2.1], triazines (OR = 1.4; 95% CI, 1.0-2.0), and any herbicide (OR = 1.4; 95% CI, 1.1-1.9). For late abortions, preconception exposure to glyphosate (OR = 1.7; 95% CI, 1.0-2.9), thiocarbamates (OR = 1.8; 95% CI, 1.1-3.0), and the miscellaneous class of pesticides (OR = 1.5; 95% CI, 1.0-2.4) was associated with elevated risks. Postconception exposures were generally associated with late spontaneous abortions. Older maternal age (> 34 years of age) was the strongest risk factor for spontaneous abortions, and we observed several interactions between pesticides in the older age group using Classification and Regression Tree analysis. This study shows that timing of exposure and restricting analyses to more homogeneous endpoints are important in characterizing the reproductive toxicity of pesticides.

Palabras clave: - Abortion, Spontaneous/*chemically induced/*epidemiology - Acetic Acids/adverse effects - Agricultural Workers' Diseases/*chemically induced/*epidemiology - Fungicides, Industrial/adverse effects - Gestational Age

- Herbicides/adverse effects - Insecticides/adverse effects - Occupational Exposure/*adverse effects - Odds Ratio - Organophosphorus Compounds - Pesticides/*adverse effects - Prenatal Exposure Delayed Effects - Retrospective Studies

- Thiocarbamates/adverse effects

PMID- 11564623

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