Broad medical research program at ccfa



Descargar 147,46 Kb.
Página1/2
Fecha de conversión01.03.2017
Tamaño147,46 Kb.
  1   2
Broad MEDICAL RESEARCH PROGRAM AT CCFA

Inflammatory Bowel Disease Grants

The Crohn’s & Colitis Foundation of America


Website: http://www.broadmedical.org
Phone: 646-484-1695

E-mail: infobmrp@ccfa.org
Questions or Issues with using proposalCENTRAL?

Please contact proposalCENTRAL Customer Support at:


pcsupport@altum.com

1-800-875-2562



New to proposalCENTRAL?

If this is your first time using proposalCENTRAL, here are some tutorials on the following topics below to help you get started:



  1. How to Register your Institution with proposalCENTRAL (Institution Officials Only)


  2. How to Register as a proposalCENTRAL user


  3. How to Create an Application using proposalCENTRAL

About Broad Medical Research Program at CCFA (BMRP-CCFA)

For more information about the Broad Medical Research Program at CCFA, please refer to our website at: http://www.broadmedical.org

To see some of our most Frequently Asked Questions, please go to http://broadmedical.org/funding/FAQ.html

Questions for Broad Medical Research Program at CCFA?

Please contact:

Michael Parks
Grants Manager
Ph: (646) 484-1695
E-mail: infobmrp@ccfa.org

TABLE OF CONTENTS

General Information


General Information 3

BMRP-CCFA Goals 3

Policies 3

Eligibility 3

Budget 3

General Submission Information 4

Letter of Interest (LOI)


LOI Information and Instructions 5

How to Apply 5

Putting Together the Letter of Interest 5

Letter of Interest Submission via proposalCENTRAL 6

Grant Application


Grant Application Information and Instructions 8

Purpose 8

Eligibility 8

Grant Review Process 8

Human and Animal Ethics Approval 9

Funding Policies 10

General Application Guidelines 11

Putting Grant Application on proposalCENTRAL 11

Title Page 11

Download Templates and Instructions 11

Enable Other Users to Access This Proposal 12

Applicant/PI 12

Institution & Contacts 12

Key Personnel 12

Summary 12

Budget Period Detail 13

Budget Summary and Justification 13

Current and Pending Support 13

Organization Assurances 14

Upload Attachments 14

PI Data Sheet 16

Validate 16

Signature Page(s) 16

Submit 16

Questions and Additional Information 16

Annual Progress Report (to replace the Continuation Application)


Progress Report Guidelines and Instructions 17

General Information 17

Review Process 18

General Progress Report Guidelines 19

Progress Report Submission 19

Summary of Project 19

Results 19

Progress Report 19

Experimental Plan for the Next Year 21

Response to Reviewers’ Comments (* only if a Year 1 Progress Report) 21

Lay Description 21

Submission Instructions 22

Questions and Additional Information 22

Example of Scheduled Items due to BMRP-CCFA


Example of Scheduled Items due to BMRP-CCFA 23

Broad MEDICAL RESEARCH PROGRAM AT CCFA

Inflammatory Bowel Disease Grants

The Crohn’s & Colitis Foundation of America


General Information
BMRP-CCFA Goals
The Broad Medical Research Program at CCFA (BMRP-CCFA) aims to help persons with inflammatory bowel diseases (IBD) by stimulating innovative, early stage research that opens new avenues for the diagnosis, therapy and prevention of these diseases. The BMRP-CCFA will consider funding clinical or basic IBD research projects that:


  • Are innovative

  • Are in the early stages of exploration

  • Will improve diagnosis, therapy or prevention of IBD; and

  • Will lead to longer-term funding by more traditional granting agencies

Proposals must be clinically relevant and must benefit patients with IBD. Proposals in the basic sciences should have clear relevance to findings and observations in IBD patients.


For more information about the BMRP-CCFA, please be sure to visit our website at http://www.broadmedical.org

Policies
ELIGIBILITY


  1. The applicant institution must be a non-profit, charitable institution, such as a university, hospital, or research organization. Applications are accepted from institutions worldwide.




  1. The applicant who wishes to take on the Principal Investigator position must have a faculty appointment at the institution or must be allowed by their institution to act as Principal Investigator. For this, we request that the applicant's university or institution (particularly the Grants and Contracts personnel) send us a statement confirming that the applicant is or is not able to apply as a Principal Investigator from his/her institution. This can be sent as a PDF attachment as part of the LOI process within proposalCENTRAL (refer to the section called “Approval Letter to Act as Principal Investigator” on Page 7).




  1. There can be only one Principal Investigator for each proposal.


BUDGET


  • Funding can be requested for up to two years, but grants generally are funded only one year at a time. Funding for a second year is based upon a satisfactory Continuation Application, which will undergo peer review (for more information, please see the section on our website called “Continuating Funding” under Policies).




  • Budgets should be appropriate for the project’s scope of work and absolute needs. All necessary costs for conduct of the study can be budgeted, including items such as personnel, supplies, equipment, publications costs and travel. There is no fixed upper or lower limit of funding, but keep in mind that we are a small foundation with limited funds. To see the range of funding we have awarded, see "Grant Funding Awarded Annually" in the "Program Statistics" section of our website.




  • Travel costs to attend the Annual BMRP-CCFA Investigator Meeting must be budgeted (see “Meetings”). Funds awarded for travel and related costs to attend the BMRP-CCFA Investigator Meeting are restricted and cannot be used for any other purpose without prior BMRP-CCFA approval. The Principal Investigator is expected to attend the two day annual meeting. Travel to attend other scientific meetings is not allowed. Other travel that is necessary to conduct the study must be fully justified and itemized separately from the BMRP-CCFA Investigator Meeting costs. Only economy airfare is allowable.




  • The maximum indirect costs/overhead that can be requested is 10% based upon total direct costs. Once a grant is awarded, funds cannot be transferred out of direct costs to cover indirect or overhead costs even if less than the maximum allowed indirect costs were requested.




  • Except as indicated above, all other rebudgeting to cover the necessary and reasonable costs of the research project is allowable without prior BMRP-CCFA approval.




  • If you have a particular project and budget in mind and wish clarification regarding whether it is appropriate, please contact us at infobmrp@ccfa.org.


General Submission Information
BMRP-CCFA applications are conducted through proposalCENTRAL. Please use the site below to access available grant opportunities and submission instructions:
https://proposalcentral.altum.com/GrantOpportunities.asp
Each applicant needs to submit a Letter of Interest (LOI) prior to sending a Full Grant Application. The Letter of Interest is mandatory for all new applications. If your LOI is approved, you will receive an e-mail with the link to submit a Full Grant Application.
Once submitted, you will receive an e-mail confirmation. If you have not received this within 48 hours of submission, please contact the BMRP-CCFA. If it is determined that some part of the application was lost or did not transfer correctly during the submission process, BMRP-CCFA has the option to “Reject” the application. If you are unsure, please contact BMRP-CCFA to ensure that the issues are addressed and corrected. If you have questions regarding the application process, contact BMRP-CCFA by phone at 646-484-1695 or via email at infobmrp@ccfa.org.

Broad MEDICAL RESEARCH PROGRAM AT CCFA

Inflammatory Bowel Disease Grants

The Crohn’s & Colitis Foundation of America



Letter of Interest

INFORMATION AND INSTRUCTIONS


How to Apply
Applicants should submit a brief Letter of Interest (up to three pages, not including attachments) as the initial request for funding. Investigators whose Letters of Interest fit the BMRP-CCFA's criteria and areas of interest will be invited to submit a Full Grant Application.
We recommend you review “Policies” and “Frequently Asked Questions” prior to preparing a Letter of Interest.
Putting Together the Letter of Interest:
Below are the following items we’ll need when putting together your PDF of the Letter of Interest:
Letter of Interest Format
The following information is part of the three-page limit:


  • Title of the project

  • Specific hypothesis or question to be investigated

  • Methodology

  • Data analysis

  • Anticipated outcomes



The following items (except for #1) are required, but not part of the three-page limit:


  1. Supportive information, such as references, preliminary data or recent publications, may be included. You may also include suggestions for potential reviewers and also indicate individuals with potential conflicts of interest.




  1. State why your project fits the BMRP-CCFA's criteria (see "BMRP Goals"), including its relevance and likely benefits to patients with IBD in the next several years.




  1. Briefly describe the laboratory or clinical environment.




  1. Indicate the estimated total budget (see “Budget” under “Policies”) and the period for which funding is requested. Keep in mind that we are interested in funding exploratory projects in order to test new ideas and directions in IBD research. Thus, funding requests should be in concert with the foundation’s purpose.




  1. Provide the principal investigator’s e-mail and postal addresses.



  2. Attach the investigator’s curriculum vitae(s) or biographical sketch(es) – INCLUDE THE CVs/BIOSKETCHES as separate attachments from the rest of the Letter of Interest

Letter of Interest Submission via proposalCENTRAL


  1. Go to https://proposalcentral.altum.com/GrantOpportunities.asp, and click "Apply Now" to access the BMRP-CCFA opportunities page.




  1. Title Page:




    1. Project Title: Fill in the project title. Do not use abbreviations unless absolutely necessary.

    2. Project Budget and Duration: Fill in the Budget information in U.S. Dollars only (please do not include cents). Fill in your estimated Project Start Date and Project End Date.




  1. Download Templates and Instructions: These are downloads for your use, if needed.



  2. Enable Other Users to Access This Proposal: Use this section if you wish to have other members of your team edit or view the application.



  3. Applicant/PI: The PI (Principal Investigator) is defined as the one person responsible to the Foundation for scientific and technical direction of the project. Please be sure to enter all required PI information here.



  4. Institution & Contacts: This is the location of where the PI is located and where the study will take place. Please enter all required Institution information here.



  5. Summary:

    1. Scientific Summary of Project

The Scientific Summary should provide a clear, concise overview of the proposed work, including the background, objective, or hypothesis and its supporting rationale; specific aims of the study for the general scientific audience.


  1. Relevance of the Project to IBD

Provide a description of how this project is explicitly related to IBD and how it will further both research and BMRP-CCFA’s mission.


  1. Attachments: Please upload the following to this section:

    1. Required for proposalCENTRAL and BMRP-CCFA:

      1. Letter of Interest

      2. PI Biosketch (or CV)



    2. Optional:

      1. Approval Letter to Act as Principal Investigator: * The applicant who wishes to take on the Principal Investigator position must have a faculty appointment at the institution. If the PI does not, then they must be allowed by their institution to act as Principal Investigator. For this, we request that the applicant's university or institution (particularly the Grants and Contracts personnel) submit to us a statement confirming that the applicant is or is not able to apply as a Principal Investigator from his/her institution.



      2. Key Personnel Biosketch / CV: If you wish to include the biosketches/CVs of other personnel (Co-Investigators, collaborators, consultants, lab technicians, etc.), attach those here.



      3. Preliminary Data: This option, along with Publications and References below, correspond with the optional supportive information located on Page 5 above.

      4. Publications

      5. References



  2. Validate / Submit: Use these sections to review your Letter of Interest submission, and once fully complete, click Submit. You are all set!


Broad MEDICAL RESEARCH PROGRAM AT CCFA

Inflammatory Bowel Disease Grants

The Crohn’s & Colitis Foundation of America



GRANT APPLICATION INFORMATION AND INSTRUCTIONS

PURPOSE

The Eli and Edythe Broad Foundation established the Broad Medical Research Program (BMRP-CCFA) for inflammatory bowel disease (IBD) research in 2001, and it merged with the Crohn’s & Colitis Foundation of America in 2014. We are interested in funding clinical or basic IBD research projects that:

a. are innovative;

b. are in the early stages of exploration; 

c. will improve diagnosis, therapy or prevention of IBD; and

d. will lead to longer-term funding by more traditional granting agencies. 

Proposals must be clinically relevant and must benefit patients with IBD. Proposals in the basic sciences should have clear relevance to findings and observations in IBD patients.

A primary purpose of BMRP-CCFA grants is to facilitate innovative IBD research to enable the Principal Investigator to obtain longer-term funding from other agencies. The crucial experiments that are necessary to validate the hypothesis should be done as early as possible in year one. If your hypothesis is confirmed by your preliminary data, we would expect you to apply for other longer-term funding during year one. Continuation support is possible if you made good progress and can document the need for a second year from the BMRP-CCFA in order to strengthen your chances for other funding.



ELIGIBILITY

The applicant institution must be a nonprofit, charitable institution, such as a university, hospital, or research organization. Applications are accepted from institutions worldwide.  

The Principal Investigator must be someone with a faculty appointment at the institution.  There can be only one Principal Investigator for each proposal.

GRANT REVIEW PROCESS

A committee does not review proposals.  Instead, leading investigators in each research area or topic write individual reviews and suggestions to improve the proposals.  Reviews are conducted anonymously to encourage candid comments. So far, more than 2,787 reviewers from 45 countries have helped the BMRP-CCFA review proposals. The reviewers do not see each other’s reviews and do not meet to forge a consensus report.  Therefore, reviews can be different or even contradictory in some of the opinions or suggestions.  The Principal Investigator receives excerpts from the reviewers’ comments that could be helpful in revising or improving the proposal.

Grant and continuation application reviewers are required to sign confidentiality agreements prior to being sent the proposals in order to protect the investigators’ ideas.

Reviewers’ comments are advisory to the BMRP-CCFA.  The final decision on grant funding is made by the BMRP-CCFA.  Grant proposals are selected for funding based on their scientific strength, innovative value, and relevance to IBD diagnosis, therapy, or prevention.  Preference is given to proposals conducted with patients or patient materials and with strong potential for clinical applicability in the foreseeable future.

Every attempt is made to ensure that there are no conflicts of interest between the investigators and their reviewers.  Principal Investigators are encouraged to inform us of potential conflicts of interest so that we can avoid them in the review process.

You may suggest the names of potential reviewers. Please provide their complete mailing address, telephone number, fax number, e-mail address and area(s) of expertise.

If you are invited to submit a grant application or a revised proposal, it is up to you to decide what is an appropriate suggestion by a reviewer.  Reviewers might not agree with each other or they could be incorrect.  If you decide not to follow some of the reviewers' suggestions, you should explain your reasons clearly in a separate "Response to the Reviewers" document.  Keep in mind that we might not use the same reviewers who evaluated your previous submission.  Should you have any questions or concerns regarding the peer reviewers' comments, we encourage you to contact us.

The reviewers of the original or revised grant application may not be the same as those who reviewed the original Letter of Interest or grant application.  We do provide a copy of the Letter of Interest reviewers’ comments to the grant application reviewers.



Grant reviewers are asked to comment on the following categories:



  1. Is the proposal scientifically sound?

  2. How innovative is this project for IBD research?

  3. Evaluate the research expertise of the investigators.

  4. Strength of support facilities and environment.

  5. Appropriateness of the budget.

  6. Provide suggestions to improve the proposal and its chances of helping patients with IBD.

  7. Overall evaluation.

HUMAN and ANIMAL ETHICS APPROVAL

Prior to any funding, applicants utilizing Human and/or Animal subjects must provide proof of appropriate institutional review committee approval for these activities. Since obtaining institutional approval for use of humans or animals may take some time, please begin this process at the same time as you write your grant proposal so that funding will not be delayed.

  • If your project involves the use of humans, please send signed approval documentation from your Institutional Review Board (IRB) or Human Ethics committee and upload it into your Grant Application submission on proposalCENTRAL. Please refer to “Human/Animal Subject Assurance” in the Upload Attachments section on Page 15.

  • If your project involves the use of animals, please send signed approval documentation from your Institutional Animal Care and Use Committee (IACUC) or Animal Ethics committee. Please refer to “Human/Animal Subject Assurance” in the Upload Attachments section on Page 15.

Please be aware that we would like you to work on securing this documentation in parallel with submitting your Grant Application. However, we do not want you to delay submitting your Grant Application to us if you have not received your approval letter(s) yet. Therefore, we request that you send us your Grant Application now, and you may submit your approval letter(s) to us at any time during the review process.

FUNDING POLICIES

  1. Funding can be requested for up to two years, but grants generally are funded only one year at a time. Funding for a second year is based upon a satisfactory Continuation Application, which will undergo peer review.

  2. Budgets should be appropriate for the project’s scope of work and absolute needs. All necessary costs for conduct of the study can be budgeted, including items such as personnel, supplies, equipment, publications costs, and travel. There is no fixed upper or lower limit of funding, but keep in mind that we are a small foundation with limited funds.

  3. Travel costs to attend the Annual BMRP-CCFA Investigator Meeting must be budgeted.  This is a two-day meeting that will tentatively be held in New York City. Funds awarded for travel and related costs to attend the BMRP-CCFA Investigator Meeting are restricted and cannot be used for any other purpose without prior BMRP-CCFA approval. Travel to attend other scientific meetings is not allowed.  Other travel that is necessary to conduct the study must be fully justified and itemized separately from the BMRP-CCFA Investigator Meeting costs. Only economy airfare is allowable.

  4. The maximum indirect costs/overhead that can be requested is 10% based upon total direct costs. Once a grant is awarded, funds cannot be transferred out of direct costs to cover indirect or overhead costs even if less than the maximum allowed indirect costs was requested.

  5. The BMRP-CCFA provides initial funding for generating preliminary data rather than serving as the final granting source for completing a project.  Utmost efforts should be made to generate sufficient preliminary data in the first year in order to compete successfully elsewhere for funding.  Funding for a second year is contingent upon demonstrated maximal progress in year one, validation of the original premise, and clear need for additional preliminary data rather than completion of a project.

GENERAL APPLICATION GUIDELINES


  1. Applications must be typed in English.

  2. The font used must be easy to read. The preferred fonts are either Arial 11 point or Times New Roman 12 point.

  3. Review the BMRP-CCFA website at http://www.broadmedical.org for the latest information about the program.

Putting Grant Application on proposalCENTRAL
  1   2


La base de datos está protegida por derechos de autor ©absta.info 2016
enviar mensaje

    Página principal